Certara.RsNLME (version 3.1.0.1)

fixedEffect: Specifies the initial values, lower bounds, upper bounds, and units for fixed effects in a model

Description

Specifies the initial values, lower bounds, upper bounds, and units for fixed effects in a model

Usage

fixedEffect(
  .Object,
  effect,
  value = NULL,
  lowerBound = NULL,
  upperBound = NULL,
  isFrozen = NULL,
  unit = NULL
)

Value

Modified NlmePmlModel object

Arguments

.Object

Model object in which to define fixed effects values

effect

Character or character vector specifying names of fixed effects

value

Numeric or numeric vector specifying the initial values of fixed effects. If supplying vector, must be in the same order/length as corresponding effect.

lowerBound

Numeric or numeric vector specifying the lower limit values of fixed effects. If supplying vector, must be in the same order as effect.

upperBound

Numeric or numeric vector specifying the upper limit values of fixed effects. If supplying vector, must be in the same order as effect.

isFrozen

Logical or logical vector. Set to TRUE to freeze the fixed effect to the specified initial value. If supplying vector, must be in the same order as effect.

unit

Character or character vector specifying units of measurement for the fixed effects. If supplying a vector, must be in the same order as effect.

Examples

model <- pkmodel(
  numCompartments = 2,
  data = pkData,
  ID = "Subject",
  Time = "Act_Time",
  A1 = "Amount",
  CObs = "Conc",
  modelName = "TwCpt_IVBolus_FOCE_ELS",
  workingDir = tempdir()
  )

 # View initial/current fixed effect values
 initFixedEffects(model)

model <-
fixedEffect(
  model,
  effect = c("tvV", "tvCl", "tvV2", "tvCl2"),
  value = c(15, 5, 40, 15)
  )