pkcovbqlData

Pharmacokinetic pediatric dataset containing 80 subjects with single bolus dose. Dataset includes covariates and observations Below Quantification Limit (BQL).

datasets

Facilitate Pharmacokinetic (PK) and Pharmacodynamic (PD) modeling
and simulation with powerful tools for Nonlinear Mixed-Effects (NLME)
modeling. The package provides access to the same advanced Maximum Likelihood
algorithms used by the NLME-Engine in the Phoenix platform. These tools support
a range of analyses, from parametric methods to individual and pooled data, and
support integrated use within the Pirana pharmacometric workbench
<doi:10.1002/psp4.70067>. Execution is supported both locally or on
remote machines.

James Craig

Certara.RsNLME

Pharmacometric Modeling

Michael Tomashevskiy

Vitalii Nazarov

Shuhua Hu

Soltanshahi Fred

Certara USA, Inc. 

pkcovbqlData function

A data frame with 880 rows and 8 variables:<dl>
 <dt>ID</dt>
<dd>Subject ID</dd> <dt>Time</dt>
<dd>Nominal Time</dd> <dt>Dose</dt>
<dd>Amount of dose</dd> <dt>CObs</dt>
<dd>Observations of drug concentration in blood</dd> <dt>LLOQ</dt>
<dd>Lower Limit of Quantification</dd> <dt>CObsBQL</dt>
<dd>Variable that indicates whether the observed drug concentration is below the limit of quantification</dd> <dt>BW</dt>
<dd>Body weight</dd> <dt>PMA</dt>
<dd>Postmenstrual age</dd>
</dl>

Format

Pharmacokinetic pediatric dataset containing 80 subjects with single bolus dose. — pkcovbqlData

A data frame with 880 rows and 8 variables:<dl>
 <dt>ID</dt>
<dd>Subject ID</dd>

 <dt>Time</dt>
<dd>Nominal Time</dd>

 <dt>Dose</dt>
<dd>Amount of dose</dd>

 <dt>CObs</dt>
<dd>Observations of drug concentration in blood</dd>

 <dt>LLOQ</dt>
<dd>Lower Limit of Quantification</dd>

 <dt>CObsBQL</dt>
<dd>Variable that indicates whether the observed drug concentration is below the limit of quantification</dd>

 <dt>BW</dt>
<dd>Body weight</dd>

 <dt>PMA</dt>
<dd>Postmenstrual age</dd>


</dl>

pkcovbqlData: Pharmacokinetic pediatric dataset containing 80 subjects with single bolus dose.

Description

Usage

Arguments

Format