An R package to uncover high-resolution protein-DNA interactions
in ChIP-exo replicates
Description
Strand specific peak-pair calling in ChIP-exo replicates.
The cumulative Skellam distribution function (package
'skellam') is used to detect significant normalised count
differences of opposed sign at each DNA strand (peak-pairs).
Irreproducible discovery rate for overlapping peak-pairs across
biological replicates is estimated using the package 'idr'.