ClinTrialPredict (version 0.0.4)

NumEventsSub.TwoArm: Calculate the expected number of events or number of subjects enrolled in a two-arm clinical trial

Description

Calculate the expected number of events or number of subjects enrolled in a two-arm clinical trial

Usage

NumEventsSub.TwoArm(
  N.0 = NULL,
  N.1 = NULL,
  ratio = NULL,
  d = NULL,
  l = NULL,
  gamma.c = NULL,
  alpha0.t = NULL,
  nu0.t = NULL,
  alpha1.t = NULL,
  nu1.t = NULL,
  s = NULL,
  m = NULL,
  design2 = NULL
)

Value

This function returns a list containing all design parameters as the same with input parameters of this function.

Arguments

N.0

number of subjects plan to be enrolled in control arm

N.1

number of subjects plan to be enrolled in experimental arm

ratio

randomization ratio between two arms: N.1 / N.0

d

expected number of events observed at time l

l

observation time

gamma.c

parameter of the exponential distribution of censoring time

alpha0.t

shape parameter of weibull survival distribution for control arm

nu0.t

scale parameter of weibull survival distribution for control arm

alpha1.t

shape parameters of weibull survival distribution for experimental arm

nu1.t

scale parameter of a weibull survival distribution for control arm

s

enrollment time

m

maximum follow-up time for a subject

design2

a list containing all the above parameters for two-arm design

Examples

# calculate the expected number of events
NumEventsSub.TwoArm(N.0=100,N.1=100,l=6,gamma.c=1,alpha0.t = 1,nu0.t=5,alpha1.t=2,nu1.t=4,s=5,m=4)

# calculate the expeTrcted number of events using a list as input
design2 <- list(N.0=100,N.1=100,l=6,gamma.c=1,alpha0.t = 1,nu0.t=5,alpha1.t=2,nu1.t=4,s=5,m=4)
NumEventsSub.TwoArm(design2=design2)

# calculate the number of subject enrolled
NumEventsSub.TwoArm(ratio=1,d=24,l=6,gamma.c=1,alpha0.t = 1,nu0.t=5,alpha1.t=2,nu1.t=4,s=5,m=4)