form_gen

Generate appropriate formula for ComBatFamily models

Provides a comprehensive framework for batch effect diagnostics, harmonization, and post-harmonization downstream analysis. Features include interactive visualization tools, robust statistical tests, and a range of harmonization techniques. Additionally, 'ComBatFamQC' enables the creation of life-span age trend plots with estimated age-adjusted centiles and facilitates the generation of covariate-corrected residuals for analytical purposes. Methods for harmonization are based on approaches described in Johnson et al., (2007) <doi:10.1093/biostatistics/kxj037>, Beer et al., (2020) <doi:10.1016/j.neuroimage.2020.117129>, Pomponio et al., (2020) <doi:10.1016/j.neuroimage.2019.116450>, and Chen et al., (2021) <doi:10.1002/hbm.25688>.

Zheng Ren

ComBatFamQC

Comprehensive Batch Effect Diagnostics and Harmonization

Andrew Chen

Elizabeth Horwath

form_gen function

<dl><dt>x</dt>
<dd>A model function name that is used or to be used in the ComBatFamily Package (eg: "lmer", "lm", "gam").</dd>
<dt>c</dt>
<dd>Data frame or matrix of covariates supplied to <code>model</code>.</dd>
<dt>i</dt>
<dd>Expression of interaction terms supplied to <code>model</code>. (eg: "age:diagnosis").</dd>
<dt>random</dt>
<dd>Variable name of a random effect in linear mixed effect model.</dd>
<dt>smooth</dt>
<dd>Variable name that requires a smooth function.</dd></dl>

Arguments

ComBatFamily Model Formula Generations — form_gen

<dl>

<dt>x</dt>
<dd>A model function name that is used or to be used in the ComBatFamily Package (eg: "lmer", "lm", "gam").</dd>


<dt>c</dt>
<dd>Data frame or matrix of covariates supplied to <code>model</code>.</dd>


<dt>i</dt>
<dd>Expression of interaction terms supplied to <code>model</code>. (eg: "age:diagnosis").</dd>


<dt>random</dt>
<dd>Variable name of a random effect in linear mixed effect model.</dd>


<dt>smooth</dt>
<dd>Variable name that requires a smooth function.</dd>

</dl>

form_gen: ComBatFamily Model Formula Generations

Description

Usage

Value

Arguments

Examples