Sstar

Returns the value of the survival function of S* at point x given the marginal distributions 
and the bivariate distributions via copula

internal

It has been designed to calculate the required sample size in randomized clinical trials with composite endpoints. It also calculates the expected effect and the probability of observing the composite endpoint, among others. The methodology can be found in Bofill & Gómez (2019) <doi:10.1002/sim.8092> and Gómez & Lagakos (2013) <doi:10.1002/sim.5547>.

Marta Roig

CompAREdesign

Statistical Functions for the Design of Studies with Composite
Endpoints

Sstar function

<dl><dt>x</dt>
<dd>Point in which to be evaluated</dd>
<dt>dist1</dt>
<dd>Distribution function of the marginal T1 (pweibull)</dd>
<dt>dist2</dt>
<dd>Distribution function of the marginal T2 (pweibull)</dd>
<dt>param1</dt>
<dd>Parameters of the marginal distribution function T1 (pweibull)</dd>
<dt>param2</dt>
<dd>Parameters of the marginal distribution function T2 (pweibull)</dd>
<dt>dist_biv</dt>
<dd>Distribution function of the bivariate distribution via copula</dd></dl>

Arguments

Survival function for composite endpoint — Sstar

<dl>

<dt>x</dt>
<dd>Point in which to be evaluated</dd>


<dt>dist1</dt>
<dd>Distribution function of the marginal T1 (pweibull)</dd>


<dt>dist2</dt>
<dd>Distribution function of the marginal T2 (pweibull)</dd>


<dt>param1</dt>
<dd>Parameters of the marginal distribution function T1 (pweibull)</dd>


<dt>param2</dt>
<dd>Parameters of the marginal distribution function T2 (pweibull)</dd>


<dt>dist_biv</dt>
<dd>Distribution function of the bivariate distribution via copula</dd>

</dl>

Sstar: Survival function for composite endpoint

Description

Usage

Arguments