AREDS

A real dataset of bivariate interval-censored data with 629 subjects and 4 non-genetic covariates and 1 genetic covariate. The dataset is selected from the Age-related Eye Disease Study (AREDS) (AREDS Group, 1999). Two events are the progression times (in years) to late-AMD in the left and right eyes.

datasets

Copula-based regression models for multivariate censored data, including
bivariate right-censored data, bivariate interval-censored data, and right/interval-censored
semi-competing risks data. Currently supports Clayton, Gumbel, Frank, Joe, AMH and
Copula2 copula models. For marginal models, it supports parametric (Weibull, Loglogistic,
Gompertz) and semiparametric (Cox and transformation) models. Includes methods for
convenient prediction and plotting. Also provides a bivariate time-to-event simulation
function and an information ratio-based goodness-of-fit test for copula. Method details
can be found in Sun et.al (2019) Lifetime Data Analysis, Sun et.al (2021) Biostatistics,
Sun et.al (2022) Statistical Methods in Medical Research, Sun et.al (2022) Biometrics, and
Sun et al. (2023+) JRSSC.

Tao Sun

CopulaCenR

Copula-Based Regression Models for Multivariate Censored Data

AREDS function

A data frame with 1258 observations (629 subjects with 2 eyes) on the following 8 variables.<dl>
 <dt><code>id</code></dt>
<dd>subject id</dd> <dt><code>ind</code></dt>
<dd>margin indicator, 1=left eye, 2=right eye</dd> <dt><code>Left</code></dt>
<dd>left bound of observed interval</dd> <dt><code>Right</code></dt>
<dd>right bound of observed interval</dd> <dt><code>status</code></dt>
<dd>censoring indicator; 1=interval-censor, 0=right censor.</dd> <dt><code>SevScaleBL</code></dt>
<dd>baseline AMD severity score, margin-specific</dd> <dt><code>ENROLLAGE</code></dt>
<dd>age at baseline</dd> <dt><code>rs2284665</code></dt>
<dd>a SNP covariate highly associated with late-AMD progression, coded as 0,1,2</dd> 
</dl>

Format

AREDS — AREDS

A data frame with 1258 observations (629 subjects with 2 eyes) on the following 8 variables.<dl>
 <dt><code>id</code></dt>
<dd>subject id</dd>

 <dt><code>ind</code></dt>
<dd>margin indicator, 1=left eye, 2=right eye</dd>

 <dt><code>Left</code></dt>
<dd>left bound of observed interval</dd>

 <dt><code>Right</code></dt>
<dd>right bound of observed interval</dd>

 <dt><code>status</code></dt>
<dd>censoring indicator; 1=interval-censor, 0=right censor.</dd>

 <dt><code>SevScaleBL</code></dt>
<dd>baseline AMD severity score, margin-specific</dd>

 <dt><code>ENROLLAGE</code></dt>
<dd>age at baseline</dd>

 <dt><code>rs2284665</code></dt>
<dd>a SNP covariate highly associated with late-AMD progression, coded as 0,1,2</dd>

 
</dl>

AREDS: AREDS

Description

Usage

Arguments

Format

Examples