CorrBin (version 1.3)

egde: EGDE data

Description

The data set is based on a developmental toxicity experiment on the effect of ethylene glycol diethyl ether (EGDE) on fetal development of New Zealand white rabbits. In the study, four groups of pregnant does were randomly assigned to dose levels $0, 25, 50$, and $100$ milligrams per kilogram body weight of EGDE. For each litter and at each dose level, the adverse response used is the combined number of fetal malformation and fetal death.

Usage

data(egde)

format

A 'CBData' object, that is a data frame with the following variables ll{ Trt factor giving treatment group ClusterSize the size of the litter NResp the number of affected fetuses Freq the number of litters with the given ClusterSize/NResp combination }

source

Krewski, D., Zhu, Y. & Fung, K. (1995). Statistical analysis of overdispersed multinomial data from developmental toxicity studies. In Statistics in Toxicology, Ed. B. Morgan, pp. 151--179. New York: Oxford University Press.

Examples

data(egde)
  stripchart(I(NResp/ClusterSize)~Trt, cex=sqrt(egde$Freq), data=egde, pch=1, 
             method="jitter", vertical=TRUE, ylab="Proportion affected")