Arterial

Data of a crossover experiment with three treatments to control arterial
pressure: treatment A is a placebo, treatments B and C are 20 and 40 mg doses
 of a test drug.
 Thus, there were six three-period sequences: ABC, ACB, BCA, BAC, CAB
 and CBA, each one of them was applied to two individuals lasting six
 weeks each. Due to ethical reasons, there was no washout period between
 the treatments. In each period, 10 consecutive measurements
 of diastolic arterial pressure were taken: 30 and 15 minutes before,
 and 15, 30, 45, 60, 75, 90, 120 and 240 minutes after
 the administration of the treatment

datasets

Analyze data from a crossover design using generalized estimation equations (GEE), including carryover effects and various correlation structures based on the Kronecker product. It contains functions for semiparametric estimates of carry-over effects in repeated measures and allows estimation of complex carry-over effects. Related work includes: a) Cruz N.A., Melo O.O., Martinez C.A. (2023). "CrossCarry: An R package for the analysis of data from a crossover design with GEE". <doi:10.48550/arXiv.2304.02440>. b) Cruz N.A., Melo O.O., Martinez C.A. (2023). "A correlation structure for the analysis of Gaussian and non-Gaussian responses in crossover experimental designs with repeated measures". <doi:10.1007/s00362-022-01391-z> and c) Cruz N.A., Melo O.O., Martinez C.A. (2023). "Semiparametric generalized estimating equations for repeated measurements in cross-over designs". <doi:10.1177/09622802231158736>.

Nelson Alirio Cruz Gutierrez

CrossCarry

Analysis of Data from a Crossover Design with GEE

Oscar Orlando Melo

Carlos Alberto Martinez

Ricardo Alberich Marti

Arterial function

A data frame with 360 rows and 5 columns:<dl>
<dt>Subject</dt>
<dd>The unique identifier of each of the patients</dd><dt>Period</dt>
<dd>The period of application of each treatment</dd><dt>Treatment</dt>
<dd>A is a placebo, treatments B and C are 20 and 40 mg doses
 of a test drug</dd><dt>Pressure</dt>
<dd>diastolic arterial pressure</dd><dt>Time</dt>
<dd>Measurement time</dd>
</dl>

Format

Arterial pressure data of crossover design — Arterial

A data frame with 360 rows and 5 columns:<dl>
<dt>Subject</dt>
<dd>The unique identifier of each of the patients</dd>

<dt>Period</dt>
<dd>The period of application of each treatment</dd>

<dt>Treatment</dt>
<dd>A is a placebo, treatments B and C are 20 and 40 mg doses
 of a test drug</dd>

<dt>Pressure</dt>
<dd>diastolic arterial pressure</dd>

<dt>Time</dt>
<dd>Measurement time</dd>


</dl>

Arterial: Arterial pressure data of crossover design

Description

Usage

Arguments

Format