DAAG (version 0.37)

ACF1: Aberrant Crypt Foci in Rat Colons

Description

Numbers of aberrant crypt foci (ACF) in the section 1 of the colons of 22 rats subjected to a single dose of the carcinogen azoxymethane (AOM), sacrificed at 3 different times.

Usage

data(ACF1)

source

Ranjana P. Bird, Faculty of Human Ecology, University of Manitoba, Winnipeg, Canada.

References

E.A. McLellan, A. Medline and R.P. Bird. Dose response and proliferative characteristics of aberrant crypt foci: putative preneoplastic lesions in rat colon. Carcinogenesis, 12(11): 2093-2098, 1991.

Examples

data(ACF1)
sapply(split(ACF1$count,ACF1$endtime),var)
plot(count ~ endtime, data=ACF1, pch=16)
pause()
print("Poisson Regression - Example 8.3")
ACF.glm0 <- glm(formula = count ~ endtime, family = poisson, data = ACF1)
summary(ACF.glm0)

# Is there a quadratic effect?
pause()

ACF.glm <- glm(formula = count ~ endtime + I(endtime^2),
  family = poisson, data = ACF1)
summary(ACF.glm)

# But is the data really Poisson?  If not, try quasipoisson:
pause()

ACF.glm <- glm(formula = count ~ endtime + I(endtime^2),
  family = quasipoisson, data = ACF1)
summary(ACF.glm)