dataDART


  This data object consists of a gene expression data matrix over 67 oestrogen receptor negative breast cancers (Wang, Y. et al. Lancet 365, 671-9 (2005)), of which 51 are basals and 16 are HER2+/ERBB2+. This classification is based on the intrinsic subtype classifier (see Hu Z, et al., BMC Genomics. 2006 Apr 27;7:96), and while not equivalent to IHC or the amplification status at the ERBB2 locus, it broadly matches these other classifications. The model pathway signature is an in-vitro derived perturbation signature reflecting ERBB2 activation (see Creighton CJ, et al., Cancer Res 2006 Apr 1;66(7):3903-11). Both data and signature are annotated with Entrez Gene IDs.


Denoising Algorithm based on Relevance network Topology
(DART) is an algorithm designed to evaluate the consistency of
prior information molecular signatures (e.g in-vitro
perturbation expression signatures) in independent molecular
data (e.g gene expression data sets). If consistent, a pruning
network strategy is then used to infer the activation status of
the molecular signature in individual samples.

Charles Shijie Zheng

DART

Denoising Algorithm based on Relevance network Topology

dataDART function

A list with 4 elements: (i) data: is the gene expression matrix described above, (ii) sign: is the ERBB2 perturbation signature, (iii) pheno: basal/ERBB2 status of samples, (iv) phenoMAINZ: basal/ERBB2 status of a further set of samples.

Format

This data object consists of a gene expression data matrix over 67 oestrogen receptor negative breast cancers (Wang, Y. et al. Lancet 365, 671-9 (2005)), of which 51 are basals and 16 are HER2+/ERBB2+. This classification is based on the intrinsic subtype classifier (see Hu Z, et al., BMC Genomics. 2006 Apr 27;7:96), and while not equivalent to IHC or the amplification status at the ERBB2 locus, it broadly matches these other classifications. The model pathway signature is an in-vitro derived perturbation signature reflecting ERBB2 activation (see Creighton CJ, et al., Cancer Res 2006 Apr 1;66(7):3903-11). Both data and signature are annotated with Entrez Gene IDs.

dataDART: Example data for DART package

Description

Usage

Arguments

Format

Examples