DMR Detection by Non-Homogeneous Hidden Markov Model from
Methylation Array Data
Description
Perform differential analysis for
methylation array data. Detect differentially
methylated regions (DMRs) from array M-values.
The core is a Non-homogeneous Hidden Markov Model
for estimating spatial correlation and a novel Constrained
Gaussian Mixture Model for modeling the M-value pairs of each individual locus.