DMRforPairs (version 1.8.0)
DMRforPairs: identifying Differentially Methylated Regions
between unique samples using array based methylation profiles
Description
DMRforPairs (formerly DMR2+) allows researchers to compare
n>=2 unique samples with regard to their methylation profile.
The (pairwise) comparison of n unique single samples distinguishes
DMRforPairs from other existing pipelines as these often
compare groups of samples in either single CpG locus or region
based analysis. DMRforPairs defines regions of interest as
genomic ranges with sufficient probes located in close
proximity to each other. Probes in one region are optionally
annotated to the same functional class(es). Differential
methylation is evaluated by comparing the methylation values
within each region between individual samples and (if the
difference is sufficiently large), testing this difference
formally for statistical significance.