DPpackage (version 1.1-0)

calgb: Cancer and Leukemia Group B (CALGB) Data

Description

Data from two studies carried out by the Cancer and Leukemia Group B (CLAGB): CALGB 8881 and CALGB 9160. In both studies, the main response was white blood cell count (WBC) for each patient over time. Mueller and Rosner (1998) used a non-linear patient specific regression model. The data consider the subject-specific regression parameters (Z1, Z2, Z3, T1, T2, B0, B1) and information on covariates.

CALGB has kindly agreed to make these data available for interested readers, subject to the following conditions: i) Any paper using these data should acknowledge CALGB for the use of the data, and ii) the paper should reference the original papers describing the studies.

Usage

data(calgb)

source

CALGB 8881: Lichtman, S. M., Ratain, M. J., Echo, D. A., Rosner, G., Egorin, M. J., Budman, D. R., Vogelzang,N. J., Norton, L. and Schilsky, R. L. (1993) Phase I trial and granulocyte-macrophage colony-stimulating factor plus high-dose cyclophosphamide given every 2 weeks: a Cancer and Leukemia Group B study. Journal of the National Cancer Institute, 85: 1319-1326.

CALGB 9160: Budman, D., Rosner, G., Lichtman, S., Miller, A., Ratain, M. and Schilsky, R. (1998) A randomized trial of wr-2721 (amifostine) as a chemoprotective agent in combination with high-dose cyclophosphamide and molgramostim (GM-CSG). Cancer Therapeutics, 1: 164-167.

References

Mueller, P. and Rosner, G. (1998). Semiparametric PK/PD Models. In: Practical Nonparametric and Semiparametric Bayesian Statistics, Eds: D. Dey, P. Muller, D. Sinha, New York: Springer-Verlag, pp. 323-337.

Mueller, P., Quintana, F. and Rosner, G. (2004). A Method for Combining Inference over Related Nonparametric Bayesian Models. Journal of the Royal Statistical Society, Series B, 66: 735-749.

Examples

data(calgb)
## maybe str(calgb) ; plot(calgb) ...