fractionation: British Institute of Radiology Fractionation Studies
Description
The British Institute of Radiology (BIR) conducted two large-scale
randomized clinical trials to assess the effectiveness of different
radiotherapy treatment schedules for cancer of the larynx and pharynx.
The cambined data come from 858 subjects with laryngeal squamous cell
carcinomas and no involvement of asjacent organs. These data have been
described and analyzed by Rezvani, Fowler, Hopewell, and Alcock (1993).
Usage
data(fractionation)
Arguments
Details
Three-year local control - meaning no detection of laryngeal carcinoma
within three years after treatment - is the binary response, coded as 1
if local control is achieved and 0 otherwise. For this data set, three-year
local control is achieved for 69 a total dose of radiation is administered in fractions over a treatment
period. The dose per fraction df is measured in grays (Gy), the length
of treatment period time is measured in days, and the number of fractions
of the dose is nf. Tumors are classified by stage (i.e., the extent of
invasion), into three groups. This categorical covariate is coded by two
indicator variables kt2 and kt3, which are defined by kt2=1 (kt3=1) is the
tumor is stage II (stage III) and zero otherwise.
Chappell, Nondahl and Fowler (1995) argued that the tumor stage, the total dose, the
total time, and the interaction of the total dose per fraction are the
relevant explanantory variables affecting probability of local control.
References
Chappell, R., Nondahl, D.M., and Fowler, J.F. (1995) Modelling Dose and
Local Control in Radiotheraphy. Journal of the American Statistical Asso-
ciation, 90: 829 - 838.
Newton, M.A., Czado, C., and Chappell, R. (1996) Bayesian inference
for semiparametric binary regression. Journal of the American Statistical
Association, 91, 142-153.
Rezvani, M., Fowler, J., Hopewell, J., and Alcock, C. (1993)
Sensitivity of Human Squamous Cell Carcinoma of the Larynx to Fractionated
Radiotherapy. British Journal of Radiology, 66: 245 - 255.
