example_drug_target_list

Drug-target interactions were downloaded and integrated from
DrugBank and ChEMBL.

datasets

It is a novel tool used to identify the candidate drugs against a particular disease based on the drug target set enrichment analysis. It assumes the most effective drugs are those with a closer affinity in the protein-protein interaction network to the specified disease. (See Gómez-Carballa et al. (2022) <doi: 10.1016/j.envres.2022.112890> and Feng et al. (2022) <doi: 10.7150/ijms.67815> for disease expression profiles; see Wishart et al. (2018) <doi: 10.1093/nar/gkx1037> and Gaulton et al. (2017) <doi: 10.1093/nar/gkw1074> for drug target information; see Kanehisa et al. (2021) <doi: 10.1093/nar/gkaa970> for the details of KEGG database.)

Junwei Han

DTSEA

Drug Target Set Enrichment Analysis

Yinchun Su

example_drug_target_list function

A data frame with 970 rows and 3 variables:<ul>
<li><code>drug_id</code>: the DrugBank ID</li>
<li><code>drug_name</code>: the name of each drug</li>
<li><code>gene_target</code>: the targets of drugs</li>
</ul>

example_drug_target_list: An example data frame of drug target lists

Description

Usage

Arguments

Format

References

Examples