For each of 2,446 drugs in the MHRA database (column 1), the number of cases with amnesia as an adverse event (column 2), and the number of cases with other adverse event for this drug (column 3). In total, 684,652 adverse drug reactions were reported, among them 2,044 cases of amnesia.
data("amnesia")data("amnesia_four_columns")
amnesia is a data.frame with 2,446 rows representing drugs
with the following two columns:
Number of the amnesia cases reported for the drug.
Number of other adverse drug reactions reported for the drug.
Thus, each line describes a 2x2 table, e.g.:
| 1-ANDROSTENEDIOL | This drug | All other drugs |
| Amnesia cases | \(X_{i, 1}\) | 2,044 - \(X_{i, 1}\) |
| Other adverse cases | \(X_{i, 2}\) | 682,648 - \(X_{i, 2}\) |
amnesia_four_columns is a data.frame with 2,446 rows
representing drugs with the following four columns:
Number of the amnesia cases reported for the drug.
Number of the amnesia cases reported for all other drugs.
Number of other adverse drug reactions reported for the drug.
Number of other adverse drug reactions reported for all other drugs.
Thus, each line describes a 2x2 table:
| 1-ANDROSTENEDIOL | This drug | All other drugs |
| Amnesia cases | \(X_{i, 1}\) | \(X_{i, 3}\) |
| Other adverse cases | \(X_{i, 2}\) | \(X_{i, 4}\) |
The data was collected from the Drug Analysis Prints published by the Medicines and Healthcare products Regulatory Agency (MHRA), by Heller & Gur. See references for more details.
R. Heller and H. Gur (2011). False discovery rate controlling procedures for discrete tests. arXiv pre-print arXiv:1112.4627v2 link.