IBScovars

A subset of the data used by (Biesheuvel and Hothorn, 2002).  The data
are part of a dose ranging trial on a compound for the treatment of the
irritable bowel syndrome with four active treatment arms, corresponding
to doses 1,2,3,4 and placebo. Note that the original dose levels have
been blinded in this data set for confidentiality. The primary endpoint
was a baseline adjusted abdominal pain score with larger values
corresponding to a better treatment effect. In total 369 patients
completed the study, with nearly balanced allocation across the doses.

datasets

The DoseFinding package provides functions for the design and analysis
	     of dose-finding experiments (with focus on pharmaceutical Phase
	     II clinical trials). It provides functions for: multiple contrast
	     tests, fitting non-linear dose-response models (using Bayesian and
	     non-Bayesian estimation), calculating optimal designs and an
	     implementation of the MCPMod methodology.

Bjoern Bornkamp

DoseFinding

Planning and Analyzing Dose Finding experiments

IBScovars function

Biesheuvel, E. and Hothorn, L. A. (2002). Many-to-one comparisons in stratified designs,
<em>Biometrical Journal</em>, <b>44</b>, 101--116

IBScovars: Irritable Bowel Syndrome Dose Response data with covariates

Description

Usage

Arguments

source