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DoseFinding (version 1.1-1)

Planning and Analyzing Dose Finding Experiments

Description

The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) ).

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Version

Install

install.packages('DoseFinding')

Monthly Downloads

2,540

Version

1.1-1

License

GPL-3

Maintainer

Bjoern Bornkamp

Last Published

November 2nd, 2023

Functions in DoseFinding (1.1-1)

critVal

Calculate critical value for multiple contrast test
migraine

Migraine Dose Response data
DR-Models

Built-in dose-response models in DoseFinding
defBnds

Calculates default bounds for non-linear parameters in dose-response models
mvpostmix

Prior to posterior updating for a multivariate normal mixture
mvtnorm.control

Control options for pmvt and qmvt functions
glycobrom

Glycopyrronium Bromide dose-response data
guesst

Calculate guesstimates based on prior knowledge
neurodeg

Neurodegenerative disease simulated longitudinal dose-finding data set
fitMod

Fit non-linear dose-response model
optDesign

Function to calculate optimal designs
planMod

Evaluate performance metrics for fitting dose-response models
Target Doses

Calculate dose estimates for a fitted dose-response model (via fitMod or bFitMod) or a Mods object.
powMCT

Calculate power for multiple contrast test
optContr

Calculate optimal contrasts
sampSize

Sample size calculations
Mods

Define dose-response models
IBScovars

Irritable Bowel Syndrome Dose Response data with covariates
MCTpval

Calculate multiplicity adjusted p-values for multiple contrast test
MCTtest

Performs multiple contrast test
bMCTtest

Performs Bayesian multiple contrast test
MCPMod

MCPMod - Multiple Comparisons and Modeling
bFitMod

Fit a dose-response model using Bayesian or bootstrap methods.
DesignMCPModApp

Start externally hosted DesignMCPMod Shiny App
DoseFinding-package

Design and Analysis of dose-finding studies
biom

Biometrics Dose Response data