migraine

Data set obtained from clinicaltrials.gov (NCT00712725). This was
randomized placebo controlled dose-response trial for treatment of acute
migraine. The primary endpoint was "pain freedom at 2 hours postdose" (a
binary measurement).

datasets

The DoseFinding package provides functions for the design and analysis
of dose-finding experiments (with focus on pharmaceutical Phase
II clinical trials). It provides functions for: multiple contrast
tests, fitting non-linear dose-response models (using Bayesian and
non-Bayesian estimation), calculating optimal designs and an
implementation of the MCPMod methodology (Pinheiro et al. (2014)
<doi:10.1002/sim.6052>).

Marius Thomas

DoseFinding

Planning and Analyzing Dose Finding Experiments

Bjoern Bornkamp

Jose Pinheiro

Frank Bretz

Ludger Sandig

Novartis Pharma AG 

migraine function

A data frame with 517 columns corresponding to the patients that
 completed the trial<dl>
 <dt><code>dose</code></dt>
<dd>a numeric vector containing the dose values</dd> <dt><code>painfree</code></dt>
<dd>number of treatment responders</dd> <dt><code>ntrt</code></dt>
<dd>number of subject per treatment group</dd> 
</dl>

Format

Migraine Dose Response data — migraine

A data frame with 517 columns corresponding to the patients that
 completed the trial<dl>
 <dt><code>dose</code></dt>
<dd>a numeric vector containing the dose values</dd>

 <dt><code>painfree</code></dt>
<dd>number of treatment responders</dd>

 <dt><code>ntrt</code></dt>
<dd>number of subject per treatment group</dd>

 
</dl>

migraine: Migraine Dose Response data

Description

Usage

Arguments

Format