generate_differential_score_graph

Computes the absolute difference of interaction scores between
the two groups. Returns a single graph with the differential score and the
differential interaction score as edge attributes. The interaction score
is computed by <code>generate_interaction_score_graphs</code>.

While it has been well established that drugs affect and help
patients differently, personalized drug response predictions remain
challenging. Solutions based on single omics measurements have been proposed,
and networks provide means to incorporate molecular interactions into reasoning.
However, how to integrate the wealth of information contained in multiple omics
layers still poses a complex problem.
We present a novel network analysis pipeline, DrDimont, Drug response prediction
from Differential analysis of multi-omics networks. It allows for comparative
conclusions between two conditions and translates them into differential drug
response predictions. DrDimont focuses on molecular interactions. It establishes
condition-specific networks from correlation within an omics layer that are
then reduced and combined into heterogeneous, multi-omics molecular networks.
A novel semi-local, path-based integration step ensures integrative conclusions.
Differential predictions are derived from comparing the condition-specific
integrated networks. DrDimont's predictions are explainable, i.e., molecular
differences that are the source of high differential drug scores can be retrieved.
Our proposed pipeline leverages multi-omics data for differential predictions,
e.g. on drug response, and includes prior information on interactions.
The case study presented in the vignette uses data published by
Krug (2020) <doi:10.1016/j.cell.2020.10.036>. The package license applies only
to the software and explicitly not to the included data.

Katharina Baum

DrDimont

Drug Response Prediction from Differential Multi-Omics Networks

Pauline Hiort

Julian Hugo

Spoorthi Kashyap

Nataniel Müller

Justus Zeinert

generate_differential_score_graph function

<dl><dt>interaction_score_graphs</dt>
<dd>[list] Named list with elements `groupA` and
`groupB` containing iGraph objects with weight and interaction_weight as edge attributes (output of
<code>generate_interaction_score_graphs</code>)</dd>
<dt>settings</dt>
<dd>[list] A named list containing pipeline settings. The settings list has to be
initialized by <code>drdimont_settings</code>. Items in the named list can be
adjusted as desired.</dd></dl>

Arguments

Compute difference of interaction score of two groups — generate_differential_score_graph

<dl>

<dt>interaction_score_graphs</dt>
<dd>[list] Named list with elements `groupA` and
`groupB` containing iGraph objects with weight and interaction_weight as edge attributes (output of
<code>generate_interaction_score_graphs</code>)</dd>


<dt>settings</dt>
<dd>[list] A named list containing pipeline settings. The settings list has to be
initialized by <code>drdimont_settings</code>. Items in the named list can be
adjusted as desired.</dd>

</dl>

generate_differential_score_graph: Compute difference of interaction score of two groups

Description

Usage

Value

Arguments

Examples