CalDEscore

Function "CalDEscore" uses gene expression to calculate differential expression level.

A systematic biology tool was developed to repurpose drugs via a drug-drug functional similarity network. 'DrugSim2DR' first predict drug-drug functional similarity  in the context of specific disease, and then using the similarity constructed a weighted drug similarity network. Finally, it used a network propagation algorithm on the network to identify drugs with significant target abnormalities as candidate drugs.

Junwei Han

DrugSim2DR

Predict Drug Functional Similarity to Drug Repurposing

Ji Li

Jiashuo Wu

CalDEscore function

<dl><dt>exp</dt>
<dd>A gene expression profile of interest (rows are genes, columns are samples).</dd>
<dt>Label</dt>
<dd>A character vector consist of "0" and "1" which represent sample class in the gene expression profile. "0" means normal sample and "1" means disease sample.</dd></dl>

Arguments

CalDEscore — CalDEscore

<dl>

<dt>exp</dt>
<dd>A gene expression profile of interest (rows are genes, columns are samples).</dd>


<dt>Label</dt>
<dd>A character vector consist of "0" and "1" which represent sample class in the gene expression profile. "0" means normal sample and "1" means disease sample.</dd>

</dl>

CalDEscore: CalDEscore

Description

Usage

Value

Arguments

Examples