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DrugVsDisease (version 2.12.0)

Comparison of disease and drug profiles using Gene set Enrichment Analysis

Description

This package generates ranked lists of differential gene expression for either disease or drug profiles. Input data can be downloaded from Array Express or GEO, or from local CEL files. Ranked lists of differential expression and associated p-values are calculated using Limma. Enrichment scores (Subramanian et al. PNAS 2005) are calculated to a reference set of default drug or disease profiles, or a set of custom data supplied by the user. Network visualisation of significant scores are output in Cytoscape format.

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Version

Version

2.12.0

License

GPL-3

Maintainer

j SaezRodriguez

Last Published

February 15th, 2017

Functions in DrugVsDisease (2.12.0)

customDB

Custom Gene Expression Profiles
selprofile

List: Differential gene expression and p-values
customsif

SIF file for custom clusters
DrugVsDisease-package

DrugVsDisease Package Overview
classifyprofile

Classify Profiles
generateprofiles

Generate Profiles
selectrankedlists

Select Ranked Lists
customClust

Custom Clusters
profiles

Gene Expression Profiles
customedge

Edge attributes for example custom network
combineProfiles

Combine Profiles