EBarrays (version 2.36.0)

utilities: Utility functions for the EBarrays package

Description

Utilitiy functions for the EBarrays package

Usage

ebPatterns(x, ordered=FALSE)

Arguments

x

x can be a character vector (of length > 2) (see example), or an arbitrary connection which should provide patterns, one line for each pattern. If x is a character vector of length 1, it is assumed to be the name of a file (since there's no point in a patterns object with only one pattern) which is then opened and treated as a connection.

ordered

logical variable specifying whether the pattern is ordered or not

Value

ebPatterns creates an Object of class ``ebarraysPatterns'', to be used in other functions such as emfit. This is nothing more than a list (and can be treated as such as far as indexing goes) and is used only for method dispatch.

Details

ebPatterns creates objects that represent a collection of hypotheses to be used by emfit.

References

Newton, M.A., Kendziorski, C.M., Richmond, C.S., Blattner, F.R. (2001). On differential variability of expression ratios: Improving statistical inference about gene expression changes from microarray data. Journal of Computational Biology 8:37-52.

Kendziorski, C.M., Newton, M.A., Lan, H., Gould, M.N. (2003). On parametric empirical Bayes methods for comparing multiple groups using replicated gene expression profiles. Statistics in Medicine 22:3899-3914.

Newton, M.A. and Kendziorski, C.M. Parametric Empirical Bayes Methods for Microarrays in The analysis of gene expression data: methods and software. Eds. G. Parmigiani, E.S. Garrett, R. Irizarry and S.L. Zeger, New York: Springer Verlag, 2003.

Newton, M.A., Noueiry, A., Sarkar, D., and Ahlquist, P. (2004). Detecting differential gene expression with a semiparametric hierarchical mixture model. Biostatistics 5: 155-176.

Yuan, M. and Kendziorski, C. (2006). A unified approach for simultaneous gene clustering and differential expression identification. Biometrics 62(4): 1089-1098.

See Also

emfit

Examples

patterns <- ebPatterns(c("1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1",
                         "1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2
                          2 2 2"), TRUE)
show(patterns)