boot_gaussian

number of bootstrap repetitions. The default is B=1000

parameter of the gaussian distribution, theta=(mean,sd)

theta

rate of the exponential distribution specifiying the censoring

size of the dataset = number of observations

Function generating bootstrap data according to a gaussian distribution (specified by a model parameter \(\theta\)),
assuming exponentially distributed right-censoring (specified by a rate C). After data generation again a model is fitted and evaluated
at a pre-specified time point \(t_0\) yielding the response vector.

We provide a non-parametric and a parametric approach to investigate the equivalence (or non-inferiority) of two survival curves, obtained from two given datasets. The test is based on the creation of confidence intervals at pre-specified time points.
For the non-parametric approach, the curves are given by Kaplan-Meier curves and the variance for calculating the confidence intervals is obtained by Greenwood's formula.
The parametric approach is based on estimating the underlying distribution, where the user can choose between a Weibull, Exponential, Gaussian, Logistic, Log-normal or a Log-logistic distribution. Estimates for the variance for calculating the confidence bands are obtained by a (parametric) bootstrap approach. For this bootstrap censoring is assumed to be exponentially distributed and estimates are obtained from the datasets under consideration.
All details can be found in K.Moellenhoff and A.Tresch: Survival analysis under non-proportional hazards: investigating non-inferiority or equivalence in time-to-event data <arXiv:2009.06699>.

boot_gaussian: Parametric Bootstrap of time-to-event data following a gaussian distribution

Description

Usage

Arguments

Value

Examples