EvidenceSynthesis (version 0.5.0)

createSimulationSettings: Create simulation settings

Description

Create an object specifying a simulation. Currently only Cox proportional hazard models are supported.

Usage

createSimulationSettings(
  nSites = 5,
  n = 10000,
  treatedFraction = 0.2,
  nStrata = 10,
  minBackgroundHazard = 2e-07,
  maxBackgroundHazard = 2e-05,
  hazardRatio = 2,
  randomEffectSd = 0
)

Value

An object of type simulationSettings, to be used in the simulatePopulations() function.

Arguments

nSites

Number of database sites to simulate.

n

Number of subjects per site. Either a single number, or a vector of length nSites.

treatedFraction

Fraction of subjects that is treated. Either a single number, or a vector of length nSites.

nStrata

Number of strata per site. Either a single number, or a vector of length nSites.

minBackgroundHazard

Minimum background hazard. Either a single number, or a vector of length nSites.

maxBackgroundHazard

Maximum background hazard. Either a single number, or a vector of length nSites.

hazardRatio

Hazard ratio.

randomEffectSd

Standard deviation of the log(hazardRatio). Fixed effect if equal to 0.

See Also

simulatePopulations

Examples

settings <- createSimulationSettings(nSites = 1, hazardRatio = 2)
populations <- simulatePopulations(settings)

# Fit a Cox regression for the simulated data site:
cyclopsData <- Cyclops::createCyclopsData(Surv(time, y) ~ x + strata(stratumId),
  data = populations[[1]],
  modelType = "cox"
)
cyclopsFit <- Cyclops::fitCyclopsModel(cyclopsData)
coef(cyclopsFit)

# (Estimates in this example will vary due to the random simulation)