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FIND (version 0.1.1)

Objective Comparison of Phase I Dose-Finding Designs

Description

Generate decision tables and simulate operating characteristics for phase I dose-finding designs to enable objective comparison across methods. Supported designs include the traditional 3+3, Bayesian Optimal Interval (BOIN) (Liu and Yuan (2015) ), modified Toxicity Probability Interval-2 (mTPI-2) (Guo et al. (2017) ), interval 3+3 (i3+3) (Liu et al. (2020) ), and Generalized 3+3 (G3). Provides visualization tools for comparing decision rules and operating characteristics across multiple designs simultaneously.

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Version

Install

install.packages('FIND')

Version

0.1.1

License

MIT + file LICENSE

Maintainer

Yunxuan Zhang

Last Published

December 15th, 2025

Functions in FIND (0.1.1)

design_constructors

Design Constructor Functions
get_decision_mtpi2

Dosing decision for the mTPI2 design
load_true

Load several commonly used scenarios
summarize_metric

Summarize after conducting simulations
get_decision_boin

Dosing decision for the BOIN design
get_decision_3plus3

Dosing decision for the 3+3 design
run_sim_3plus3

Simulations for the 3+3 design.
oc_plot

Generate Operating Characteristics Plots with S3 Support
get_decision_g3plus3

Dosing decision for the G3 design
get_decision_i3plus3

Dosing decision for the i3+3 design
run_sim_boin

Simulations for the BOIN design.
run_sim_g3plus3

Simulations for the G3 design.
run_sim_i3plus3

Simulations for the i3+3 design.
run_sim_mtpi2

Simulations for the mTPI2 design.
decision_table

Generate Decision Tables with S3 Support
select_mtd

Select the maximum tolerated dose (MTD) using isotonic regression
run_simulation

Run Simulations for Phase I Dose-Finding Designs
FIND-package

FIND: Compare Objective Decision Tables for Phase I Dose-Finding Designs
generate_decision_table

Generate the decision table(s) for a single or multiple designs
generate_oc_plot

Generate the plot(s) displaying operating characteristics for a single or multiple designs
get_decision

Generate Decision Tables for Phase I Dose-Finding Designs