beta_binomial_wald

Implements Wald test using beta-binomial distribution to account for
overdispersion in count data. Useful when variance exceeds that expected
under binomial distribution.

internal

A compositional statistical framework for absolute proportion
estimation between fractions in RNA sequencing data. 'FracFixR' addresses
the fundamental challenge in fractionated RNA-seq experiments where library
preparation and sequencing depth obscure the original proportions of RNA
fractions. It reconstructs original fraction proportions using non-negative
linear regression, estimates the "lost" unrecoverable fraction, corrects
individual transcript frequencies, and performs differential proportion
testing between conditions. Supports any RNA fractionation protocol including
polysome profiling, sub-cellular localization, and RNA-protein complex isolation.

Alice Cleynen

FracFixR

Compositional Statistical Framework for RNA Fractionation
Analysis

Agin Ravindran

Nikolay Shirokikh

beta_binomial_wald function

<dl><dt>counts</dt>
<dd>Total count matrix</dd>
<dt>successes</dt>
<dd>Success count matrix (not proportions)</dd>
<dt>annotation</dt>
<dd>Sample metadata</dd></dl>

Arguments

beta_binomial_wald: Beta-Binomial Wald Test — beta_binomial_wald

<dl>

<dt>counts</dt>
<dd>Total count matrix</dd>


<dt>successes</dt>
<dd>Success count matrix (not proportions)</dd>


<dt>annotation</dt>
<dd>Sample metadata</dd>

</dl>

beta_binomial_wald: beta_binomial_wald: Beta-Binomial Wald Test

Description

Usage

Value

Arguments