ebb_loglik

An internal function only (doesn't do error checking or take care of boundary cases).
The log-likelihood (log-PMF) calculation for the Extended Beta-Binomial proposed by Prentice (1986).
Takes in a vectorized argument because we apply() it in run_BB_GBJ().

internal

Offers the Generalized Berk-Jones (GBJ) test for set-based inference in genetic
association studies. The GBJ is designed as an alternative to tests such as Berk-Jones (BJ),
Higher Criticism (HC), Generalized Higher Criticism (GHC), Minimum p-value (minP), and Sequence
Kernel Association Test (SKAT). All of these other methods (except for SKAT) are also implemented
in this package, and we additionally provide an omnibus test (OMNI) which integrates information from each of the tests.
The GBJ has been shown to outperform other tests in genetic association studies when signals
are correlated and moderately sparse. Please see the vignette for a quickstart guide or Sun and Lin
(2017) <arXiv:1710.02469> for more details.

Ryan Sun

Generalized Berk-Jones Test for Set-Based Inference in Genetic
Association Studies

ebb_loglik function

<dl><dt>x</dt>
<dd>A vector of length 3 with (1) value of outcome (2) mu parameter (3) gamma parameter</dd>
<dt>d</dt>
<dd>The number of test stsatistics in the set</dd></dl>

Arguments

ebb_loglik.R — ebb_loglik

<dl>

<dt>x</dt>
<dd>A vector of length 3 with (1) value of outcome (2) mu parameter (3) gamma parameter</dd>


<dt>d</dt>
<dd>The number of test stsatistics in the set</dd>

</dl>

ebb_loglik: ebb_loglik.R

Description

Usage

Value

Arguments

Examples