GRAB.SimubVec

Generates random effect vectors (bVec) that account for family relationships
through kinship-based correlation structures.

Provides a comprehensive suite of genome-wide association study (GWAS) methods
specifically designed for biobank-scale data, including but not limited to, robust approaches
for time-to-event traits (Li et al., 2025 <doi:10.1038/s43588-025-00864-z>) and ordinal
categorical traits (Bi et al., 2021 <doi:10.1016/j.ajhg.2021.03.019>). The package also offers
general frameworks for GWAS of any trait type (Bi et al., 2020 <doi:10.1016/j.ajhg.2020.06.003>),
while accounting for sample relatedness (Xu et al., 2025 <doi:10.1038/s41467-025-56669-1>) or
population structure (Ma et al., 2025 <doi:10.1186/s13059-025-03827-9>). By accurately
approximating score statistic distributions using saddlepoint approximation (SPA), these
methods can effectively control type I error rates for rare variants and in the presence of
unbalanced phenotype distributions. Additionally, the package includes functions for simulating
genotype and phenotype data to support research and method development.

Woody Miao

GRAB

Genome-Wide Robust Analysis for Biobank Data (GRAB)

Wenjian Bi

Wei Zhou

Rounak Dey

Zhangchen Zhao

Seunggeun Lee

GRAB.SimubVec function

<dl><dt>nSub</dt>
<dd>Number of unrelated subjects. If 0, all subjects are related.</dd>
<dt>nFam</dt>
<dd>Number of families. If 0, all subjects are unrelated.</dd>
<dt>FamMode</dt>
<dd>Family structure: "4-members", "10-members", or "20-members".
See <code>GRAB.SimuGMat</code> for pedigree details.</dd>
<dt>tau</dt>
<dd>Variance component for random effects.</dd></dl>

Arguments

Simulate random effects based on family structure — GRAB.SimubVec

<dl>

<dt>nSub</dt>
<dd>Number of unrelated subjects. If 0, all subjects are related.</dd>


<dt>nFam</dt>
<dd>Number of families. If 0, all subjects are unrelated.</dd>


<dt>FamMode</dt>
<dd>Family structure: "4-members", "10-members", or "20-members".
See <code>GRAB.SimuGMat</code> for pedigree details.</dd>


<dt>tau</dt>
<dd>Variance component for random effects.</dd>

</dl>

GRAB.SimubVec: Simulate random effects based on family structure

Description

Usage

Value

Arguments

Details