Spline Based Window Boundaries for Genomic Analyses
Description
Defines window or bin boundaries for the analysis of genomic data.
Boundaries are based on the inflection points of a cubic smoothing spline
fitted to the raw data. Along with defining boundaries, a technique to
evaluate results obtained from unequally-sized windows is provided.
Applications are particularly pertinent for, though not limited to, genome
scans for selection based on variability between populations (e.g. using
Wright's fixations index, Fst, which measures variability in subpopulations
relative to the total population).