The Average Mutual Information Profile (AMIP) detects long-range correlations in a given DNA sequence by estimating the shared information between nucleotides situated k bases apart.
Usage
AMIP(fasta_file, n1 = 1, n2 = 4)
Value
This function returns a data frame containing the mutual information values for the specified nucleotide positions.
Arguments
fasta_file
Path to the input FASTA file containing the DNA sequence.
n1
The starting position (in bases) for Mutual Information calculation.
n2
The end position (in bases) for Mutual Information calculation.
Author
Dr. Anu Sharma,
Dr. Shashi Bhushan Lal
Details
The Average Mutual Information (AMI) provides a statistical estimate of the shared information between nucleotides situated k bases apart in the DNA sequence, where k ranges from n1 to n2. This method helps identify potential patterns or correlations in the nucleotide arrangement.
References
Bauer, M., Schuster, S. M., & Sayood, K. (2008). The average mutual information profile as a genomic signature. BMC Bioinformatics, 9(1), 48.