annotateHiCBin

A GRanges object containing the Hi-C blocking regions.

HiC_bin.GR

A GRanges object containing the genomic feature intervals with fold-enrichments (score).

GenomicFeature.GR

This is an internal function (should not be used). Function to compute the average of the coverage of ChIP-seq peaks within blocking regions.

Here we propose a model to systematically analyze the roles of architectural proteins and functional elements in blocking long-range contacts between loci. The proposed model does not rely on topologically associating domain (TAD) mapping from Hi-C data. Instead of testing the enrichment or influence of protein binding at TAD borders, the model directly estimates the blocking effect of proteins on long-range contacts between flanking loci, making the model intuitive and biologically meaningful.

annotateHiCBin: Annotate blocking regions with ChIP-seq data.

Description

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