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curveRep finds representative curves from a
relatively large collection of curves. The curves usually represent
time-response profiles as in serial (longitudinal or repeated) data
with possibly unequal time points and greatly varying sample sizes per
subject. After excluding records containing missing x or
y, records are first stratified into kn groups having similar
sample sizes per curve (subject). Within these strata, curves are
next stratified according to the distribution of x points per
curve (typically measurement times per subject). The
clara clustering/partitioning function is used
to do this, clustering on one, two, or three x characteristics
depending on the minimum sample size in the current interval of sample
size. If the interval has a minimum number of unique values of
one, clustering is done on the single x values. If the minimum
number of unique x values is two, clustering is done to create
groups that are similar on both min(x) and max(x). For
groups containing no fewer than three unique x values,
clustering is done on the trio of values min(x), max(x),
and the longest gap between any successive x. Then within
sample size and x distribution strata, clustering of
time-response profiles is based on p values of y all
evaluated at the same p equally-spaced x's within the
stratum. An option allows per-curve data to be smoothed with
lowess before proceeding. Outer x values are
taken as extremes of x across all curves within the stratum.
Linear interpolation within curves is used to estimate y at the
grid of x's. For curves within the stratum that do not extend
to the most extreme x values in that stratum, extrapolation
uses flat lines from the observed extremes in the curve unless
extrap=TRUE. The p y values are clustered using
clara.
print and plot methods show results. By specifying an
auxiliary idcol variable to plot, other variables such
as treatment may be depicted to allow the analyst to determine for
example whether subjects on different treatments are assigned to
different time-response profiles. To write the frequencies of a
variable such as treatment in the upper left corner of each panel
(instead of the grand total number of clusters in that panel), specify
freq.
curveSmooth takes a set of curves and smooths them using
lowess. If the number of unique x points in a curve is
less than p, the smooth is evaluated at the unique x
values. Otherwise it is evaluated at an equally spaced set of
x points over the observed range. If fewer than 3 unique
x values are in a curve, those points are used and smoothing is not done.
curveRep(x, y, id, kn = 5, kxdist = 5, k = 5, p = 5,
force1 = TRUE, metric = c("euclidean", "manhattan"),
smooth=FALSE, extrap=FALSE, pr=FALSE)# S3 method for curveRep
print(x, …)
# S3 method for curveRep
plot(x, which=1:length(res), method=c('all','lattice'),
m=NULL, probs=c(.5, .25, .75), nx=NULL, fill=TRUE,
idcol=NULL, freq=NULL, plotfreq=FALSE,
xlim=range(x), ylim=range(y),
xlab='x', ylab='y', colorfreq=FALSE, …)
curveSmooth(x, y, id, p=NULL, pr=TRUE)
a numeric vector, typically measurement times.
For plot.curveRep is an object created by curveRep.
a numeric vector of response values
a vector of curve (subject) identifiers, the same length as
x and y
number of curve sample size groups to construct.
curveRep tries to divide the data into equal numbers of
curves across sample size intervals.
maximum number of x-distribution clusters to derive
using clara
maximum number of x-y profile clusters to derive using clara
number of x points at which to interpolate y
for profile clustering. For curveSmooth is the number of
equally spaced points at which to evaluate the lowess smooth, and if
p is omitted the smooth is evaluated at the original x
values (which will allow curveRep to still know the x
distribution
By default if any curves have only one point, all curves
consisting of one point will be placed in a separate stratum. To
prevent this separation, set force1 = FALSE.
see clara
By default, linear interpolation is used on raw data to
obtain y values to cluster to determine x-y profiles.
Specify smooth = TRUE to replace observed points with
lowess before computing y points on the grid.
Also, when smooth is used, it may be desirable to use
extrap=TRUE.
set to TRUE to use linear extrapolation to
evaluate y points for x-y clustering. Not recommended unless
smoothing has been or is being done.
set to TRUE to print progress notes
an integer vector specifying which sample size intervals
to plot. Must be specified if method='lattice' and must be a
single number in that case.
The default makes individual plots of possibly all
x-distribution by sample size by cluster combinations. Fewer may be
plotted by specifying which. Specify method='lattice'
to show a lattice xyplot of a single sample size interval,
with x distributions going across and clusters going down.
the number of curves in a cluster to randomly sample if there
are more than m in a cluster. Default is to draw all curves
in a cluster. For method = "lattice" you can specify
m = "quantiles" to use the xYplot function to show
quantiles of y as a function of x, with the quantiles
specified by the probs argument. This cannot be used to draw
a group containing n = 1.
applies if m = "quantiles". See xYplot.
3-vector of probabilities with the central quantile first. Default uses quartiles.
for method = "all", by default if a sample size
x-distribution stratum did not have enough curves to stratify into
k x-y profiles, empty graphs are drawn so that a matrix of
graphs will have the next row starting with a different sample size
range or x-distribution. See the example below.
a named vector to be used as a table lookup for color
assignments (does not apply when m = "quantile"). The names of
this vector are curve ids and the values are color names or
numbers.
a named vector to be used as a table lookup for a grouping
variable such as treatment. The names are curve ids and
values are any values useful for grouping in a frequency tabulation.
set to TRUE to plot the frequencies from the
freq variable as horizontal bars instead of printing them.
Applies only to method = "lattice". By default the largest bar
is 0.1 times the length of a panel's x-axis. Specify
plotfreq = 0.5 for example to make the longest bar half this long.
set to TRUE to color the frequencies printed by
plotfreq using the colors provided by idcol.
plotting parameters. Default ranges are
the ranges in the entire set of raw data given to curveRep.
arguments passed to other functions.
a list of class "curveRep" with the following elements
a hierarchical list first split by sample size intervals,
then by x distribution clusters, then containing a vector of cluster
numbers with id values as a names attribute
a table of frequencies of sample sizes per curve after
removing NAs
total number of records excluded due to NAs
a table of frequencies of number of NAs
excluded per curve
cut points for sample size intervals
number of sample size intervals
number of clusters on x distribution
number of clusters of curves within sample size and distribution groups
number of points at which to evaluate each curve for clustering
input data after removing NAs
In the graph titles for the default graphic output, n refers to the
minimum sample size, x refers to the sequential x-distribution
cluster, and c refers to the sequential x-y profile cluster. Graphs
from method = "lattice" are produced by
xyplot and in the panel titles
distribution refers to the x-distribution stratum and
cluster refers to the x-y profile cluster.
Segal M. (1994): Representative curves for longitudinal data via regression trees. J Comp Graph Stat 3:214-233.
Jones MC, Rice JA (1992): Displaying the important features of large collections of similar curves. Am Statistician 46:140-145.
Zheng X, Simpson JA, et al (2005): Data from a study of effectiveness suggested potential prognostic factors related to the patterns of shoulder pain. J Clin Epi 58:823-830.
# NOT RUN {
# Simulate 200 curves with pre-curve sample sizes ranging from 1 to 10
# Make curves with odd-numbered IDs have an x-distribution that is random
# uniform [0,1] and those with even-numbered IDs have an x-dist. that is
# half as wide but still centered at 0.5. Shift y values higher with
# increasing IDs
set.seed(1)
N <- 200
nc <- sample(1:10, N, TRUE)
id <- rep(1:N, nc)
x <- y <- id
for(i in 1:N) {
x[id==i] <- if(i %% 2) runif(nc[i]) else runif(nc[i], c(.25, .75))
y[id==i] <- i + 10*(x[id==i] - .5) + runif(nc[i], -10, 10)
}
w <- curveRep(x, y, id, kxdist=2, p=10)
w
par(ask=TRUE, mfrow=c(4,5))
plot(w) # show everything, profiles going across
par(mfrow=c(2,5))
plot(w,1) # show n=1 results
# Use a color assignment table, assigning low curves to green and
# high to red. Unique curve (subject) IDs are the names of the vector.
cols <- c(rep('green', N/2), rep('red', N/2))
names(cols) <- as.character(1:N)
plot(w, 3, idcol=cols)
par(ask=FALSE, mfrow=c(1,1))
plot(w, 1, 'lattice') # show n=1 results
plot(w, 3, 'lattice') # show n=4-5 results
plot(w, 3, 'lattice', idcol=cols) # same but different color mapping
plot(w, 3, 'lattice', m=1) # show a single "representative" curve
# Show median, 10th, and 90th percentiles of supposedly representative curves
plot(w, 3, 'lattice', m='quantiles', probs=c(.5,.1,.9))
# Same plot but with much less grouping of x variable
plot(w, 3, 'lattice', m='quantiles', probs=c(.5,.1,.9), nx=2)
# Smooth data before profiling. This allows later plotting to plot
# smoothed representative curves rather than raw curves (which
# specifying smooth=TRUE to curveRep would do, if curveSmooth was not used)
d <- curveSmooth(x, y, id)
w <- with(d, curveRep(x, y, id))
# Example to show that curveRep can cluster profiles correctly when
# there is no noise. In the data there are four profiles - flat, flat
# at a higher mean y, linearly increasing then flat, and flat at the
# first height except for a sharp triangular peak
set.seed(1)
x <- 0:100
m <- length(x)
profile <- matrix(NA, nrow=m, ncol=4)
profile[,1] <- rep(0, m)
profile[,2] <- rep(3, m)
profile[,3] <- c(0:3, rep(3, m-4))
profile[,4] <- c(0,1,3,1,rep(0,m-4))
col <- c('black','blue','green','red')
matplot(x, profile, type='l', col=col)
xeval <- seq(0, 100, length.out=5)
s <- x <!-- %in% xeval -->
matplot(x[s], profile[s,], type='l', col=col)
id <- rep(1:100, each=m)
X <- Y <- id
cols <- character(100)
names(cols) <- as.character(1:100)
for(i in 1:100) {
s <- id==i
X[s] <- x
j <- sample(1:4,1)
Y[s] <- profile[,j]
cols[i] <- col[j]
}
table(cols)
yl <- c(-1,4)
w <- curveRep(X, Y, id, kn=1, kxdist=1, k=4)
plot(w, 1, 'lattice', idcol=cols, ylim=yl)
# Found 4 clusters but two have same profile
w <- curveRep(X, Y, id, kn=1, kxdist=1, k=3)
plot(w, 1, 'lattice', idcol=cols, freq=cols, plotfreq=TRUE, ylim=yl)
# Incorrectly combined black and red because default value p=5 did
# not result in different profiles at x=xeval
w <- curveRep(X, Y, id, kn=1, kxdist=1, k=4, p=40)
plot(w, 1, 'lattice', idcol=cols, ylim=yl)
# Found correct clusters because evaluated curves at 40 equally
# spaced points and could find the sharp triangular peak in profile 4
# }
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