SingleMiRNA_CRModel

Function "SingleMiRNA_CRModel" uses survival data to build a multivariate Cox model using the targets of a single miRNA.

A systematic biology tool was developed to identify dysregulated miRNAs via a miRNA-miRNA interaction network. 'IDMIR' first constructed a weighted miRNA interaction network through integrating miRNA-target interaction information, molecular function data from Gene Ontology (GO) database and gene transcriptomic data in specific-disease context, and then, it used a network propagation algorithm on the network to identify significantly dysregulated miRNAs.

Junwei Han

IDMIR

Identification of Dysregulated MiRNAs Based on MiRNA-MiRNA
Interaction Network

Xilong Zhao

Jiashuo Wu

SingleMiRNA_CRModel function

<dl><dt>ExpData</dt>
<dd>A gene expression profile of interest (rows are genes, columns are samples).</dd>
<dt>MiRNA</dt>
<dd>A miRNA ID.</dd>
<dt>cutoff.point</dt>
<dd>A numeric value is used to divide high-risk and low-risk groups.</dd>
<dt>SurvivalData</dt>
<dd>Survival data (the column names are: "sample", "status", "time") corresponding to samples in the gene expression profile of interest.</dd></dl>

Arguments

SingleMiRNA_CRModel — SingleMiRNA_CRModel

<dl>

<dt>ExpData</dt>
<dd>A gene expression profile of interest (rows are genes, columns are samples).</dd>


<dt>MiRNA</dt>
<dd>A miRNA ID.</dd>


<dt>cutoff.point</dt>
<dd>A numeric value is used to divide high-risk and low-risk groups.</dd>


<dt>SurvivalData</dt>
<dd>Survival data (the column names are: "sample", "status", "time") corresponding to samples in the gene expression profile of interest.</dd>

</dl>

SingleMiRNA_CRModel: SingleMiRNA_CRModel

Description

Usage

Value

Arguments

Examples