Computes the derivative of the loglikelihood function relevant to optimizing the reference cancer profile, mm, for step 1
ISOpureS1.model_optimize.mm.mm_deriv_loglikelihood(ww, tumordata, model)the mm_weights, with G entries
a GxD matrix representing gene expression profiles of tumor samples
list containing all the parameters to be optimized
The negative derivative the likelihood function relevant to optimizing mm. The derivative is taken not with respect to mm but with respect to unconstrained variables via a change of variables.