iDMC


This data set lists pre-selected iDMCs for all TCGA cancer types.


The proportion of cancer cells in solid tumor sample, known as the tumor purity, has adverse impact on a variety of data analyses if not properly accounted for. We develop 'InfiniumPurify', which is a comprehensive R package for estimating and accounting for tumor purity based on DNA methylation Infinium 450k array data. 'InfiniumPurify' provides functionalities for tumor purity estimation. In addition, it can perform differential methylation detection and tumor sample clustering with the consideration of tumor purities.

Yufang Qin

InfiniumPurify

Estimate and Account for Tumor Purity in Cancer Methylation Data
Analysis

iDMC function

A list containing informative Differential methylation CpG sites (iDMC) and their average methylation levels in tumor and normal samples.

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X. Zheng, N. Zhang, H.J. Wu and H. Wu, Estimating and accounting for tumor purity in the analysis of DNA methylation data from cancer studies. <em>Genome biology</em>, accepted.

iDMC: iDMC

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