kog.mwut

<p>A dataframe with three columns, 'seq' (gene id),'term' (KOG class) and 'value' (continuous measure, such as log fold-change).</p>

<p>Tailedness of the MWU test: two-tailed ("t"), greater-than ("g"), or less-than ("l")</p>

Alternative

Rank-based tests for enrichment of KOG (euKaryotic Orthologous Groups) classes with up- or down-regulated genes based on a continuous measure. The meta-analysis is based on correlation of KOG delta-ranks across datasets (delta-rank is the difference between mean rank of genes belonging to a KOG class and mean rank of all other genes). With binary measure (1 or 0 to indicate significant and non-significant genes), one-tailed Fisher's exact test for over-representation of each KOG class among significant genes will be performed.

Mikhail Matz

kog.mwut: Mann-Whitney U test for KOG enrichment.

Description

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References