CCM.pvals


  Gene p-value list derived from knock-out experiments of the three CCM genes CCM1, CCM2 and CCM3.
  Contains p-values obtained from a limma differential expression analysis of knock-out samples versus control samples (each done in triplicate).


datasets

Implements the method described in "Network-based analysis of omics data: The LEAN method" [Gwinner Boulday (2016) <DOI:10.1093/bioinformatics/btw676>]
Given a protein interaction network and a list of p-values describing a measure of interest (as e.g. differential gene expression) this method
computes an enrichment p-value for the protein neighborhood of each gene and compares it to a background distribution of randomly drawn p-values.
The resulting scores are corrected for multiple testing and significant hits are returned in tabular format.

Frederik Gwinner

LEANR

Finds "Local Subnetworks" Within an Interaction Network which
Show Enrichment for Differentially Expressed Genes

CCM.pvals function

Named list (CCM1,2,3) of named numericals (names = gene ids, values = limma p-values)

CCM.pvals: Gene p-value list derived from knock-out experiments of the three CCM genes

Description

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