
 igraph graph object used in examples for function run.lean.fromdata.
 Obtained by parsing the STRING v.91 murine interaction network and restricting 
 it to proteins mappable to genes contained on the Affymetrix MouseGene v1.0 ST chip.


datasets

Implements the method described in "Network-based analysis of omics data: The LEAN method" [Gwinner Boulday (2016) <DOI:10.1093/bioinformatics/btw676>]
Given a protein interaction network and a list of p-values describing a measure of interest (as e.g. differential gene expression) this method
computes an enrichment p-value for the protein neighborhood of each gene and compares it to a background distribution of randomly drawn p-values.
The resulting scores are corrected for multiple testing and significant hits are returned in tabular format.

g2: igraph graph object used in examples for function run.lean.fromdata

Description

Usage

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Source