loadSpectraMzML

Conduct automated cell-based assays using Matrix-Assisted Laser Desorption/Ionization (MALDI) methods for high-throughput screening of signals responsive to treatments. The package efficiently identifies high variance signals and fits dose-response curves to them. Quality metrics such as Z', V', log2FC, and CRS are provided for evaluating the potential of signals as biomarkers. The methodologies were introduced by Weigt et al. (2018) <doi:10.1038/s41598-018-29677-z> and refined by Unger et al. (2021) <doi:10.1038/s41596-021-00624-z>.

Thomas Enzlein

MALDIcellassay

Automated MALDI Cell Assays Using Dose-Response Curve Fitting

loadSpectraMzML function

<dl><dt>Dir</dt>
<dd>Character, parent directory of spectra.</dd>
<dt>filter</dt>
<dd>Character vector, filter out spectra which match the given vector.</dd>
<dt>nameSpectra</dt>
<dd>Logical, if TRUE the spectra in the resulting list will be named according to the dirname.</dd>
<dt>verbose</dt>
<dd>Logical, print logs to console</dd></dl>

Arguments

load mzML spectra — loadSpectraMzML

<dl>

<dt>Dir</dt>
<dd>Character, parent directory of spectra.</dd>


<dt>filter</dt>
<dd>Character vector, filter out spectra which match the given vector.</dd>


<dt>nameSpectra</dt>
<dd>Logical, if TRUE the spectra in the resulting list will be named according to the dirname.</dd>


<dt>verbose</dt>
<dd>Logical, print logs to console</dd>

</dl>

loadSpectraMzML: load mzML spectra

Description

Usage

Value

Arguments

Examples