cubeKillerRescue

Conversion of K allele to R allele, a basal mutation rate

Keff

Aeff

Genotype-specific sex ratio at emergence

Genotype-specific multiplicative modifier of adult mortality

omega

Genotype-specific female pupatory success

Genotype-specific male pupatory success

Genotype-specific fractional reduction(increase) in fertility

This function creates an inheritance cube to model a Killer-Rescue system.
Killer-Rescue is a 2-locus system: one locus has a toxin and the other locus contains
the antidote. The loci are assumed independent and are non-homing. 
This drive has 3 alleles at locus 1 and 2 alleles and locus 2:<ul>
<li>Locus 1<ul>
<li>T: Wild-type allele</li>
<li>K: "Killer" toxin allele</li>
<li>R: Broken toxin allele</li>
</ul></li>
<li>Locus 2<ul>
<li>W: Wild-type allele</li>
<li>A: Antidote allele</li>
</ul></li>
</ul>

Provides a model designed to be a reliable testbed where various gene
drive interventions for mosquito-borne diseases control. It is being developed to
accommodate the use of various mosquito-specific gene drive systems within a
population dynamics framework that allows migration of individuals between patches
in landscape. Previous work developing the population dynamics can be found in Deredec et al.
(2001) <doi:10.1073/pnas.1110717108> and Hancock & Godfray (2007) <doi:10.1186/1475-2875-6-98>,
and extensions to accommodate CRISPR homing dynamics in Marshall et al. (2017)
<doi:10.1038/s41598-017-02744-7>.

cubeKillerRescue: Inheritance Cube: Killer-Rescue System

Description

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