cubeRIDL

Genotype-specific sex ratio at emergence

Genotype-specific multiplicative modifier of adult mortality

omega

Genotype-specific female pupatory success

Genotype-specific male pupatory success

Genotype-specific fractional reduction(increase) in fertility

This function creates a RIDL system.
RIDL (Release of Insects with Dominant Lethality), is a form of SIT.
Created by Oxitec, this is based on a positive feedback loop using the
toxic tTAV gene, controlled under lab conditions by the TetO promoter.
This has 2 alleles at 1 locus<ul>
<li>W: Wild-type allele</li>
<li>R: OX513 RIDL allele</li>
</ul>

Provides a model designed to be a reliable testbed where various gene
drive interventions for mosquito-borne diseases control. It is being developed to
accommodate the use of various mosquito-specific gene drive systems within a
population dynamics framework that allows migration of individuals between patches
in landscape. Previous work developing the population dynamics can be found in Deredec et al.
(2001) <doi:10.1073/pnas.1110717108> and Hancock & Godfray (2007) <doi:10.1186/1475-2875-6-98>,
and extensions to accommodate CRISPR homing dynamics in Marshall et al. (2017)
<doi:10.1038/s41598-017-02744-7>.

cubeRIDL: Inheritance Cube: RIDL (Release of Insects with Dominant Lethality)

Description

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