This is a sex-specific version of a split CRISPR drive. At one locus is the Cas9, inherited in a Mendelian fashion. At a second, unlinked, locus are the gRNAs. When the two loci occur together, the gRNAs drive, with potential damaged alleles, but the Cas9 remains Mendelian. It is assumed that this is an autosomal drive. This drive corresponds to the confinable gene drive system developed by the Akbari lab.
cubeSplitDrive(
cM = 1,
chM = 0,
crM = 0,
ccM = cM,
cchM = chM,
ccrM = crM,
cF = 1,
chF = 0,
crF = 0,
ccF = cF,
cchF = chF,
ccrF = crF,
dW = 0,
dhW = 0,
drW = 0,
ddW = dW,
ddhW = dhW,
ddrW = drW,
eta = NULL,
phi = NULL,
omega = NULL,
xiF = NULL,
xiM = NULL,
s = NULL
)Cutting efficiency in males, one Cas9 allele
Homing efficiency in males, one Cas9 allele
Resistance efficiency in males, one Cas9 allele
Cutting efficiency in males, two Cas9 alleles
Homing efficiency in males, two Cas9 alleles
Resistance efficiency in males, two Cas9 alleles
Cutting efficiency in females, one Cas9 allele
Homing efficiency in females, one Cas9 allele
Resistance efficiency in females, one Cas9 allele
Cutting efficiency in females, two Cas9 alleles
Homing efficiency in females, two Cas9 alleles
Resistance efficiency in females, two Cas9 alleles
Maternal deposition cutting, one Cas9 allele
Maternal deposition homing, one Cas9 allele
Maternal deposition resistance, one Cas9 allele
Maternal deposition cutting, two Cas9 alleles
Maternal deposition homing, two Cas9 alleles
Maternal deposition resistance, two Cas9 alleles
Genotype-specific mating fitness
Genotype-specific sex ratio at emergence
Genotype-specific multiplicative modifier of adult mortality
Genotype-specific female pupatory success
Genotype-specific male pupatory success
Genotype-specific fractional reduction(increase) in fertility
Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.