MaxLik-class

An object containing the estimate produced using the maximum-likelihood method as well as various statistics.

Encodes several methods for performing Mendelian randomization
analyses with summarized data. Summarized data on genetic associations with the
exposure and with the outcome can be obtained from large consortia. These data
can be used for obtaining causal estimates using instrumental variable methods.

Stephen Burgess

MendelianRandomization

Mendelian Randomization Package

Olena Yavorska

James Staley

Fernando Hartwig

Jim Broadbent

Christopher Foley

Andrew Grant

Amy Mason

Ting Ye

Haoran Xue

Zhaotong Lin

Siqi Xu

Ashish Patel

Hyunseung Kang

Sheng Wang

Ville Karhunen

MaxLik-class function

<dl>
<dt><code>Model</code></dt>
<dd>The model used for estimation: fixed-effect (<code>"fixed"</code>) or random-effects (<code>"random"</code>).</dd></dl>
<dt><code>Exposure</code></dt>
<dd>The name of the exposure variable.</dd>
<dt><code>Outcome</code></dt>
<dd>The name of the outcome variable.</dd>
<dt><code>Correlation</code></dt>
<dd>The matrix of correlations between genetic variants.</dd>
<dt><code>Psi</code></dt>
<dd>The correlations between genetic associations with the exposure and with the outcome.</dd>
<dt><code>Estimate</code></dt>
<dd>The causal point estimate from the inverse-variance weighted method.</dd>
<dt><code>StdError</code></dt>
<dd>The standard error associated with <code>Estimate</code>.</dd>
<dt><code>CILower</code></dt>
<dd>The lower bound of the confidence interval for <code>Estimate</code> based on <code>StdError</code>.</dd>
<dt><code>CIUpper</code></dt>
<dd>The upper bound of the confidence interval for <code>Estimate</code> based on <code>StdError</code>.</dd>
<dt><code>Alpha</code></dt>
<dd>The significance level used in constructing the confidence interval (default is 0.05).</dd>
<dt><code>Pvalue</code></dt>
<dd>P-value associated with the causal estimate.</dd>
<dt><code>SNPs</code></dt>
<dd>The number of SNPs that were used in the calculation.</dd>
<dt><code>RSE</code></dt>
<dd>The estimated residual standard error from the regression model.</dd>
<dt><code>Heter.Stat</code></dt>
<dd>Heterogeneity statistic (likelihood ratio statistic) and associated p-value: the null hypothesis is that all genetic variants estimate the same causal parameter; rejection of the null is an indication that one or more variants may be pleiotropic.</dd>

Slots

MaxLik Class — MaxLik-class

<dl>
<dt><code>Model</code></dt>
<dd>The model used for estimation: fixed-effect (<code>"fixed"</code>) or random-effects (<code>"random"</code>).</dd>


<dt><code>Exposure</code></dt>
<dd>The name of the exposure variable.</dd>


<dt><code>Outcome</code></dt>
<dd>The name of the outcome variable.</dd>


<dt><code>Correlation</code></dt>
<dd>The matrix of correlations between genetic variants.</dd>


<dt><code>Psi</code></dt>
<dd>The correlations between genetic associations with the exposure and with the outcome.</dd>


<dt><code>Estimate</code></dt>
<dd>The causal point estimate from the inverse-variance weighted method.</dd>


<dt><code>StdError</code></dt>
<dd>The standard error associated with <code>Estimate</code>.</dd>


<dt><code>CILower</code></dt>
<dd>The lower bound of the confidence interval for <code>Estimate</code> based on <code>StdError</code>.</dd>


<dt><code>CIUpper</code></dt>
<dd>The upper bound of the confidence interval for <code>Estimate</code> based on <code>StdError</code>.</dd>


<dt><code>Alpha</code></dt>
<dd>The significance level used in constructing the confidence interval (default is 0.05).</dd>


<dt><code>Pvalue</code></dt>
<dd>P-value associated with the causal estimate.</dd>


<dt><code>SNPs</code></dt>
<dd>The number of SNPs that were used in the calculation.</dd>


<dt><code>RSE</code></dt>
<dd>The estimated residual standard error from the regression model.</dd>


<dt><code>Heter.Stat</code></dt>
<dd>Heterogeneity statistic (likelihood ratio statistic) and associated p-value: the null hypothesis is that all genetic variants estimate the same causal parameter; rejection of the null is an indication that one or more variants may be pleiotropic.</dd>


</dl>

MaxLik Class

MaxLik-class: MaxLik Class

Description

Arguments

Slots