loglikelihood

param

Genetic associations with the exposure.

Standard errors of associations with the exposure.

sigmax

Genetic associations with the outcome.

Standard errors of genetic associations with the outcome.

sigmay

Internal function for calculating log-likelihood for for maximum-likelihood method.

internal

Encodes several methods for performing Mendelian randomization
analyses with summarized data. Summarized data on genetic associations with the
exposure and with the outcome can be obtained from large consortia. These data
can be used for obtaining causal estimates using instrumental variable methods.

Stephen Burgess

MendelianRandomization

Mendelian Randomization Package

loglikelihood function

<dl><dt>param</dt>
<dd>Parameters in the model.</dd>
<dt>x</dt>
<dd>Genetic associations with the exposure.</dd>
<dt>sigmax</dt>
<dd>Standard errors of associations with the exposure.</dd>
<dt>y</dt>
<dd>Genetic associations with the outcome.</dd>
<dt>sigmay</dt>
<dd>Standard errors of genetic associations with the outcome.</dd></dl>

Arguments

Calculates log-likelihood with uncorrelated variants in two-sample setting (no correlation from sample overlap) — loglikelihood

<dl>

<dt>param</dt>
<dd>Parameters in the model.</dd>


<dt>x</dt>
<dd>Genetic associations with the exposure.</dd>


<dt>sigmax</dt>
<dd>Standard errors of associations with the exposure.</dd>


<dt>y</dt>
<dd>Genetic associations with the outcome.</dd>


<dt>sigmay</dt>
<dd>Standard errors of genetic associations with the outcome.</dd>

</dl>

loglikelihood: Calculates log-likelihood with uncorrelated variants in two-sample setting (no correlation from sample overlap)

Description

Usage

Value

Arguments

Details