Perform the Meta-Analysis for Pathway Enrichment Analysis (MAPE)
Description
Perform the Meta-analysis for Pathway Enrichment (MAPE)
methods introduced by Shen and Tseng (2010). It includes functions to
automatically perform MAPE_G (integrating multiple studies at
gene level), MAPE_P (integrating multiple studies at pathway
level) and MAPE_I (a hybrid method integrating MAEP_G and
MAPE_P methods). In the simulation and real data analyses in
the paper, MAPE_G and MAPE_P have complementary advantages and
detection power depending on the data structure. In general,
the integrative form of MAPE_I is recommended to use. In the
case that MAPE_G (or MAPE_P) detects almost none pathway, the
integrative MAPE_I does not improve performance and MAPE_P (or
MAPE_G) should be used. Reference: Shen, Kui, and George C
Tseng. Meta-analysis for pathway enrichment analysis when
combining multiple microarray studies.Bioinformatics (Oxford,
England) 26, no. 10 (April 2010): 1316-1323.
doi:10.1093/bioinformatics/btq148.
http://www.ncbi.nlm.nih.gov/pubmed/20410053.