plot.proto

A proto R object which obtained by MetaQC function.

It draws a PCA biplot which shows the four QC measures. CQCg and AQCg are combined to be CAQCg, and CQCp and AQCp are combined to be CAQCp to reduce the dominance of CQC and AQC due to their greater correlation.

MetaAnalysis

Microarray

QualityControl

MetaQC implements our proposed quantitative quality
        control measures: (1) internal homogeneity of co-expression
        structure among studies (internal quality control; IQC); (2)
        external consistency of co-expression structure correlating
        with pathway database (external quality control; EQC); (3)
        accuracy of differentially expressed gene detection (accuracy
        quality control; AQCg) or pathway identification (AQCp); (4)
        consistency of differential expression ranking in genes
        (consistency quality control; CQCg) or pathways (CQCp). (See
        the reference for detailed explanation.) For each quality
        control index, the p-values from statistical hypothesis testing
        are minus log transformed and PCA biplots were applied to
        assist visualization and decision. Results generate systematic
        suggestions to exclude problematic studies in microarray
        meta-analysis and potentially can be extended to GWAS or other
        types of genomic meta-analysis. The identified problematic
        studies can be scrutinized to identify technical and biological
        causes (e.g. sample size, platform, tissue collection,
        preprocessing etc) of their bad quality or irreproducibility
        for final inclustion/exclusion decision.

plot.proto: Plot MetaQC results.

Description

Usage

Arguments

Value

References

See Also

Examples