A DNA methylation classifier tool for the identification of
pediatric brain tumor subtypes
Description
Classification of pediatric tumors into biologically
defined subtypes is challenging and multifaceted approaches are
needed. For this aim, we developed a diagnostic classifier
based on DNA methylation profiles. We offer MethPed as an
easy-to-use toolbox that allows researchers and clinical
diagnosticians to test single samples as well as large cohorts
for subclass prediction of pediatric brain tumors. The current
version of MethPed can classify the following tumor
diagnoses/subgroups: Diffuse Intrinsic Pontine Glioma (DIPG),
Ependymoma, Embryonal tumors with multilayered rosettes (ETMR),
Glioblastoma (GBM), Medulloblastoma (MB) - Group 3 (MB_Gr3),
Group 4 (MB_Gr3), Group WNT (MB_WNT), Group SHH (MB_SHH) and
Pilocytic Astrocytoma (PiloAstro).