MAcancer


     Cancer Gene expression data of glioblastoma patients from the TCGA project. 
     A set of 14 genes that have been shown in the literature to be involved in 
     differential methylation in glioblastoma were selected as an example to try 
     out MethylMix.


MethylMix is an algorithm implemented to identify hyper
and hypomethylated genes for a disease. MethylMix is based on a
beta mixture model to identify methylation states and compares
them with the normal DNA methylation state. MethylMix uses a
novel statistic, the Differential Methylation value or DM-value
defined as the difference of a methylation state with the
normal methylation state. Finally, matched gene expression data
is used to identify, besides differential, functional
methylation states by focusing on methylation changes that
effect gene expression.

Olivier Gevaert

MethylMix

MethylMix: Identifying methylation driven cancer genes.

MAcancer function

Format

Source

Cancer Gene expression data of glioblastoma patients from the TCGA project. 
     A set of 14 genes that have been shown in the literature to be involved in 
     differential methylation in glioblastoma were selected as an example to try 
     out MethylMix.

MAcancer: Cancer Gene expression data of glioblastoma patients from the TCGA project.

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